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Hey MMA Fans, for today’s we will be covering the TOP 10 WORST MMA INJURIES OF ALL TIME. The video includes Jon Jones, Anderson Silva, Shogun Rua and many more! If you enjoyed the video make sure to drop a LIKE and SUBSCRIBE if you’re new! Also don’t forget to hit that NOTIFICATION BELL to always stay tuned in on for our new content! What is YOUR top 10?
Check out 10 THINGS YOU DIDN’T KNOW ABOUT JORGE MASVIDAL below:
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Check out WORST TRASH TALKERS IN MMA HISTORY (Cody Garbrandt, Colby Covington, Tito Ortiz) below:
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CRAZIEST CELEBRATIONS IN MMA HISTORY (Jorge Masvidal, Conor McGregor, Jose Aldo) below:
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Follow along with First Aid, or with my notes which can be found here: https://www.dropbox.com/sh/dylkj0bomn3dy7r/AADkMDWMstA0GCcTivBlId0Va?dl=0
This video will be on B cell and T cell disorders. Now just to preface it, know that T cells are seen more in viral and fungi infections. So in more viral and fungal infections, think of T cell disorders. Now that’s out of the way, let’s talk about B cell disorders.
1) X linked agammaglobulinemia: this is a mutation in bruton tyrosine kinase, which is needed to mature B cells and make plasma cells. Without this, there are no plasma cells and no immunoglobulins! This will show up at 6 months due to the loss of maternal antibodies.
2) Selective IgA deficiency: with a loss of IgA, you have more mucosal and respiratory and GIT infections. It is also linked to atopic diseases and allergic blood transfusion reaction.
3) Common variable immunodeficiency: this is a multifactorial disorder in class switching. This leads to variable decrease in immunoglobulin. Done with B cell disorderse, let’s discuss T cell disorders.
1) 22q11.2 deletion syndrome: Also known as DiGeorge Syndrome. This is the failure of the third and fourth pharyngeal pouch to develop, which lead to a loss of the thymus. Without a thymus, there is no T cells! On chest x-ray (CXR), there is a loss of thymic shadow. Now these pouches also make your parathyroid. Without your parathyroid and PTH, you have low blood calcium. Lastly, systemic manifestations include cardiac abnormalities and abnormal facies.
2) IL-12 receptor deficiency: without functional IL-12, you lower TH1 and IFN-Y. This leads to a decrease in T cells and macrophage recruitment which leads to infectious of mycobacterium and fungi. The first sign is after administration of TB vaccine.
3) Hyper IgE syndrome: this is a mutation in STAT3 which controls cytokines and growth factors. Some cytokines it can’t release will be IL-12! Therefore there are similar signs, however, without other cytokines you have cold abscesses. Also with low IL-12, you have an increase in TH2 which leads to IgE and eosinophils and atopic diseases like eczema. That’s the cytokine part, how about the growth factors? With abnormal growth factors you have coarse facies, and retained primary teeth.
4) Our last one is chronic mucocutaneous candida: this is just candida over your skin and mucus membranes.
Now let’s combine them and talk about combined B cell and T cell disorders!
1) SCID – severe combined immunodeficiency: there are many ways to get SCID, but the most common is IL2 receptor deficiency. Another cause of SCID is adenosine deaminase deficiency which is an enzyme used in your purine salvage pathway. Due to the mitotic activity of T/B cells, a deficiency in this leads to decreased immune cells. Deficiency leads to loss of follicles, thymus or T-cell receptor excision circles.
2) Ataxia telangiectasia: this is due to an ATM mutation which normally repairs dsDNA breaks. Some signs include ataxia and telangiectasia! Labs show increased alpha fetoprotein.
3) Hyper IgM: this is a XLR disorder of your CD40. This leads to an inability to class switch. Therefore your default IgM will increase.
4) Wiskott aldrich: this is due to a mutation in WASP gene which helps regulate the cytoskeleton and receptors. You can see increased igE and IgA which can lead to eczema. Also your platelets can be dysfunctional leading to thrombocytopenia and bleeding.
Our last topic will be on phagocyte disorders! Let’s finish up with chediak higashi syndrome. This is due to defective LYST gene which leads to microtubule dysfunction. This leads to dysfunctional phagolysosomes. On blood smear, there are massive granules. The dead giveaway is albinism, due to loss of transport of melanin. Video Rating: / 5
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We’ve harnessed electricity, sequenced the human genome, and eradicated smallpox. But after billions of dollars in research, we haven’t found a solution for a disease that affects more than 14 million people and their families at any given time. Why is it so difficult to cure cancer? Kyuson Yun explains the challenges.
Lesson by Kyuson Yun, directed by Artrake Studio.
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Mukamik, Tushar Sharma, Dmitry Neverov, Mohammad Khory, Goh Xiang Ting Diana, Umar Farooq, Kevin Wong, Activated Classroom Teaching, Constantin Salagor, Daniel Mardale, Monica Grace Ward, Dawn Jordan, Yanira Santamaria, Prasanth Mathialagan, Savannah Scheelings, Yalda A., Susan Herder, Be Owusu, Samuel Doerle, David Rosario.
As many as half of runners get injured every year. Watch to see what steps you can take to stay strong and pain-free mile after mile. Get more healthy living tips from the Mayo Clinic App: http://mayocl.in/2tbMb57
Ankle sprains, Achilles tendinopathy, runners knee, plantar fasciitis and more, they’re all common running injuries, but how do you know if you actually have one of these injuries? To help you identify niggles and pains in the future, Heather is here to help with some tips on how to limit them!
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Did you know that when running you can be putting a force two to three times your body weight through your feet and legs? It’s, therefore, no surprise that so many of us pick up various pains, niggles, and injuries over the years from running.
So, to help you identify any of these niggles and pains in the future, Heather is going to run through a bunch of the most common, and tips on how to limit them!
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The Global Triathlon Network (GTN) is the world’s biggest triathlon YouTube channel, with new videos every day! GTN is for anyone who loves triathlon: from seasoned triathletes to first timers – and everyone in between!
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Let’s learn about the letter J in this Letter J Song for Kids animated song and video! We will learn words that start with J and animals that start with J. It’s so much fun to learn about the letter J with 123ABCtv.
Our alphabet videos help kids of all ages learn about the alphabet. From a to z, we want to help kids learn their letters in a super simple and fun way. From babies and toddlers, to preschool and kindergarten age children, learning the english alphabet is a blast! Let’s learn about the letter J!
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The Killer Bees were uncompromising race cars that cut an earsplitting path through the European countryside. In 1986, after just three years of racing including several fatal accidents involving drivers and spectators, the killer bees of FISA Group B were outlawed. -WARNING- it gets loud at the very end..
As the World Rally Championship headed to Corsica for its 2019 event, David Evans and Colin Clark visited the corner where Henri Toivonen and co-driver Sergio Cresto were killed in a crash that effectively signalled the end of rallying’s spectacular but frighteningly dangerous Group B era. As well as paying their respects, they outline why there is still to this day so much mystery around the crash that happened in 1986.
